Kerosene spray combustion and self-extinguishing behaviors were experimentally studied in a ceiling vented compartment with various injecting pressures and ceiling vent sizes. The parameters including flame height, oxygen concentration and self-extinguishing time et al. were considered. The results show that the combustion process can be divided into three stages. e.g. growth stage, quasi-steady stage and self-extinguishing stage. Both injecting pressure and ceiling vent size have significant effects on the flame height. At the growth stage, the increase of injecting pressure or vent size results in a higher maximum flame height. However, when spray flame reaches quasi-steady stage, the flame height mainly depends on injecting pressure and the vent size effect can be almost negligible. The dimensionless average flame height at the quasi-steady stage was found to be well correlated with dimensionless heat release rate. Moreover, the self-extinguishing behavior was also investigated and both the oxygen concentration and self-extinguishing time are significantly influenced by injecting pressure and vent size. With the increase of injecting pressure, the self-extinguishing time is evidently shortened, while increasing the vent dimension has an opposite effect. Furthermore, the parameters (Q)over dot/V root A and V(Q) over dot/root A were proposed for evaluating the coupled effects of injecting pressure and vent size on oxygen concentration and self-extinguishing time, respectively. The corresponding correlations were also developed, and moreover the predicted value agree well with the experimental data.