SAFETY AND IMMUNOGENICITY OF HYDROGEN PEROXIDE-INACTIVATED PERTUSSIS TOXOID IN 18-MONTH-OLD CHILDREN

Type of Publication

Year of Publication

1991

Authors

G.R. Siber; N. Thakrar; B.A. Yancey; L. Herzog; C. Todd; N. Cohen; R.D. Sekura; C.U. Lowe

Abstract

The immunogenicity and adverse effects of an acellular pertussis vaccine consisting of a purified pertussis toxin inactivated with hydrogen peroxide (PTxd) was evaluated. Children aged 15 to 30 months were injected with 10 (n = 33) or 50-mu-g (n = 34) of PTxd or with diphtheria and tetanus toxoids and whole cell pertussis vaccine (DTP) (n = 34). All children had previously received three doses of DTP during infancy. Both dosages of PTxd induced higher IgG antibody (p

DOI

10.1016/0264-410x(91)90289-i

Volume

9

Notes

Times Cited: 27 27