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Correlations between no observed effect level and selected parameters of the chemical structure for veterinary drugs

Type of Publication
Year of Publication
2010
Authors

T. Grabowski; J.Jan Jaroszewski; W. Piotrowski

Abstract

No observed effect level (NOEL) represents the lowest value among numerous parameters used for the analysis of risk and the safety of a chemical substance and medicinal product. In the present study, the correlation between NOEL and selected topological parameters was determined for a group of 135 veterinary drugs. Due to the high values of the standard deviation for most of the parameters, the method of NOEL mean values analysis in quintile groups was used. The direct correlations between NOEL and the partition coefficient octanol/water (LogKOW), logarithm of water solubility value (LogSw), polar surface area (PSA), apolar surface area (aPSA), hydrogen bond acceptors and hydrogen bond donors were very low. In quintile groups a significant correlation (P

DOI

10.1016/j.tiv.2010.01.003

Volume

24

Notes

3

Pagination

953-9

Number
3
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