Type of Publication
Year of Publication
2000
Authors

Q.J.W. Milner; B.C. Guard; J.G. Allen

Abstract

A number of methods exist by which the pH of local anaesthetic solutions may be increased. Most commonly, these require the addition of differing amounts of sodium bicarbonate solution according to the local anaesthetic drugs. Sodium bicarbonate (1%2 was titrated against pH in six commonly used local anaesthetic solutions. Titration curves of pH and volume of sodium bicarbonate solution added are shown for this group of local anaesthetics. This study demonstrates that 1 mL of 1%2sodium bicarbonate solution may be used to alkalinize this range of local anaesthetics without the risk of precipitation. We also conclude that Ropivacaine (at concentration 0.75%2and 1.0%2, is unsuitable for alkalinization since it precipitates at a pH of 6.0.

DOI

10.1046/j.1365-2346.2000.00596.x

Volume

17

Notes

Times Cited: 16 16

Pagination

38-42

Number
1
ISSN Number

0265-0215