The viability and public acceptance of the hydrogen and fuel cell (HFC) systems and infrastructure depends on their robust safety engineering design, education and training of the workforce, regulators and other stakeholders in the state-of-the-art in the field. This can be provided only through building up and maturity of the hydrogen safety engineering (HSE) profession. HSE is defined as an application of scientific and engineering principles to the protection of life, property and environment from adverse effects of incidents/accidents involving hydrogen. This paper describes a design framework and overviews a structure and contents of technical sub-systems for carrying out HSE. The approach is similar to British standard BS7974 for application of fire safety engineering to the design of buildings and expanded to reflect on specific for hydrogen safety related phenomena, including but not limited to high pressure under-expanded leaks and dispersion, spontaneous ignition of sudden hydrogen releases to air, deflagrations and detonations, etc. The HSE process includes three main steps. Firstly, a qualitative design review is undertaken by a team that can incorporate owner, hydrogen safety engineer, architect, representatives of authorities having jurisdiction, e.g. fire services, and other stakeholders. The team defines accident scenarios, suggests trial safety designs, and formulates acceptance criteria. Secondly, a quantitative safety analysis of selected scenarios and trial designs is carried out by qualified hydrogen safety engineer(s) using the state-of-the-art knowledge in hydrogen safety science and engineering and validated models and tools. Finally, the performance of a HFC system and/or infrastructure under the trial safety designs is assessed against predefined by the team acceptance criteria. This performance-based methodology offers the flexibility to assess trial safety designs using separately or simultaneously three approaches: deterministic, comparative or combined probabilistic/deterministic.