Fuel cell vehicles that use high-pressure hydrogen gas as a fuel should be able to immediately release hydrogen gas from the cylinder through pressure relief devices (PRDs) in the event of a vehicle fire. The release through PRDs prevents the cylinder from exploding due to the increased pressure of hydrogen gas, but the method of releasing the gas needs to be specified in order to avoid secondary disaster due to the spread of fire. Since hydrogen cylinders for fuel cell buses are different in terms of installation location and size from those for ordinary vehicles, the location of PRDs and the release direction of hydrogen gas should be separately examined. For example, the improper locations of PRDs would raise the possibility of explosion because of a delay in temperature rise, and the direct release of hydrogen gas from a cylinder installed on the rooftop of the bus may disperse the flame over a wide area. In this study, the bonfire test and high-pressure hydrogen release test were conducted assuming a vehicle fire of a fuel cell bus.