During the filling of hydrogen tanks high temperatures can be generated inside the vessel because of the gas compression while during the emptying low temperatures can be reached because of the gas expansion. Excessively high or excessively low temperatures could affect the mechanical properties of the tank materials. CFD analyses of the filling and emptying processes have been performed in the HyTransfer project. To assess the accuracy of the CFD model the simulation results have been compared with new experimental data for different filling and emptying strategies. A satisfactory agreement between experiments and simulations is shown for the temperatures of the gas inside the tank, for the temperatures at the interface between the liner and the composite material, and for the temperatures on the external surface of the vessel.