In the present study, the phenomena of blast wave and fireball generated by high pressure (35 MPa) hydrogen tank (72 l) rupture have been investigated numerically. The realizable k- turbulence model was applied. The simulation of the combustion process is based on the eddy dissipation model coupled with the one step chemical reaction mechanism. Simulation results are compared with experimental data from a stand-alone hydrogen fuel tank rapture following a bonfire test. The model allows the study of the interaction between combustion process and blast wave propagation. Simulation results (blast wave overpressure, fireball shape and size) follow the trends observed in the experiment.