The effect of confinement on the magnitude of overpressure due to a gaseous detonation of a hydrogen-air mixture was studied with the aid of numerical simulations. A simplified combustion reaction kinetic model applied along with computational fluid dynamics (CFD) allowed for the numerical simulation of large-scale detonations of hydrogen-air mixtures. The model was validated against experimental data reported in the literature for the case of a large-scale (300 m3) surface (unconfined space) detonation of a hydrogen-air mixture and the results of a hydrogen-air (confined space) detonation test performed in a 263 m3 tunnel facility. The predicted overpressure and detonation velocity was in agreement with the measurements in both unconfined and confined detonation cases. To verify the effect of confinement on the magnitude of the blast wave overpressure due to detonation of a combustible gas cloud, a series of CFD simulations of hydrogen detonations followed by propagation of a non-reactive blast wave in various geometries were carried out. The results were compared with the correlation applicable for unconfined detonations, which was also found to be applicable for partially confined detonations after the transformation of the distance from explosion centre to spherical blast wave equivalent radius. (c) 2021 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.