An experimental investigation on the effects of continuous semicircular curved structure on spontaneous ignition during pressurized hydrogen suddenly release was conducted. An S-shaped tube with 700 mm in length and 10 mm in diameter was used in our experiments, and a straight tube with the same configuration was adopted for comparison. The results show that the continuously generated rarefaction waves and reflected shock waves make the pressure curves in the S-shaped tube more complicated. Meanwhile, the mean velocity and intensity of the leading shock wave undergo considerable attenuation when it propagates in the S-shaped structure. By comparing with the straight tube, the minimum critical pressure condition for spontaneous ignition in the Sshaped tube is slightly difficult to reach, but the difference is not huge. Nevertheless, the S-shaped structure can effectively promote hydrogen-air mixing and make combustion more intense. A secondary overpressure peak detected by the pressure transducer near the nozzle occurs in the spontaneous ignition cases and no such pressure increase is caught in the non-ignition cases. The transition from spontaneous combustion flame to a jet flame at the nozzle and the complete out-tube jet flame development process are captured and discussed.