The control of hydrogen in the containment is an important safety issue following rapid oxidation of the uncovered reactor core during a severe accident in a Nuclear Power Plant (NPP), because dynamic pressure loads from eventual hydrogen combustion can be detrimental to the structural integrity of the reactor safety systems and the reactor containment. In the set of our previous papers, a CFD-based method to assess the consequence of fast combustion of uniform hydrogen-air mixtures was presented, followed by its validation for hydrogen-air mixtures with diluents and for non-uniform hydrogen-air mixtures. In the present paper, the extension of this model for the slow deflagration regime is presented and validated using the hydrogen deflagration experiments performed in the medium-scale experimental facility THAI. The proposed method is implemented in the CFD software ANSYS Fluent using user defined functions. The paper describes the combustion model and the main results of code validation. It addresses questions regarding turbulence model selection, effect of heat transfer mechanisms, and grid sensitivity, as well as provides insights into the importance of combustion model choice for the slow deflagration regime of hydrogen combustion in medium-scale and large-scale experimental vessels mimicking the NPP containment. (C) 2016 Elsevier B.V. All rights reserved.