Air pollution and traffic congestion are two of the major issues affecting public authorities, policy makersand citizens not only in Italy and European Union but worldwide; this is nowadays witnessed by alwaysmore frequent limitations to the traffic in most of Italian cities, for instance.Hydrogen use in automotive appears to offer a viable solution in medium-long term; this new perspectiveinvolves the need to carry out adequate infrastructures for distribution and refuelling, and consequently theneed to improve knowledge on hydrogen technologies from a safety point of view.In the present work possible different configurations for gaseous hydrogen refuelling station has beencompared: ?stand-alone? and ?multi-fuel?.These two alternative scenarios has been taken into consideration, each of one with specific hypotheses:?stand-alone? configuration, based on the hypothesis of a potential model consisting of a hydrogen refuellingstation composed by on-site hydrogen production via electrolysis, a trailer of compressed gas for back-up,compressor unit, intermediate storage unit and dispenser. In this model it is assumed that no other refuellingequipment and/or dispenser of traditional fuel is present in the same site.?multi-fuel? configuration, where it is assumed that the same components for hydrogen refuelling station areplaced in the same site beside one or more refuelling equipment and/or dispenser of traditional fuel.Comparisons have been carried out from the point of view of specific risk assessment, which have beenconducted on both the two alternative scenarios.