Abstract
This paper presents a concept for an implantable micro-pump based on hydrogen-generating gas cells. The gas-generating cell is separated from the drug reservoir by an expandable latex membrane. The system offers linear drug delivery with flowrates ranging from 8 nl/s to 2 microl/s and a total delivery volume of up to 160 ml. Drugs can be dispensed over a wide backpressure range. The device is scalable based on the size of the gas-producing cell and requires no external energy source. Possible fields of application include in vivo local drug delivery for chemotherapy, diabetes, and pain management.
Year of Publication
2011
Journal
Proc Inst Mech Eng H
Volume
225
Number of Pages
1196-201
ISBN Number
0954-4119 (Print)
0954-4119 (Linking)
0954-4119 (Linking)
Accession Number
22320059
DOI
10.1177/0954411911423348