Integrated Safety Management (ISM) is a comprehensive process that systematically reviews a company's or project's requirements. Programs are evaluated to identify similarities and gaps in requirement implementation. ISM provides the justification to coordinate and eliminate duplicated efforts. Proactive incorporation of new or revised requirements is possible; thus new reaction-based programs are avoided. This improves safety and reduces compliance costs. In addition, the ISM gap identification process helps reduce potential liabilities and improves hazard management. Hydrogen industries and demonstration projects must comply with multiple statues, rules, regulations, codes and standards. These requirements are typically developed to address a specific topic (e.g., public safety, environmental protection, or worker health). Companies and projects have developed many programs to address each topic as new requirements are identified or added. This results in multiple programs that have similar but uncoordinated procedures. The Savannah River Site (SRS) is a Department of Energy nuclear production facility in Aiken, South Carolina. A wide variety of laboratory, industrial, chemical and nuclear operations have been conducted since it was built in the early 1950's. Within this mix of activities is a varied set of overlapping requirements. This paper describes how SRS has successfully blended safety, health, nuclear/radiation safety, emergency preparedness and environmental programs using the ISM process. The paper also describes how ISM has been applied to a hydrogen demonstration project. This program has widespread applicability to other companies, facilities and projects that face multiple safety and regulatory requirements.