The three years European MATHRYCE project, dedicated to material testing and design recommendations for components exposed to hydrogen enhanced fatigue, started in October 2012. Its main goal is to provide an ?easy? to implement methodology based on lab-scale experimental tests under hydrogen gas to assess the service life of a real scale component taking into account fatigue loading under hydrogen gas. Dedicated experimental tests will be developed for this purpose. In the present paper, the proposed approach is presented and compared to the methodologies currently developed elsewhere in the world.